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Cause of Alzheimer’s disease traced to mutation in common enzyme – EurekAlert

Researchers from Tokyo Metropolitan University have discovered a new mechanism by which clumps of tau protein are created in the brain, killing brain cells and…

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IMAGE: The mutant MARK4 creates a form of tau which accumulates easily in brain cells, causing neurons to die.
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Credit: Tokyo Metropolitan University
Tokyo, Japan – Researchers from Tokyo Metropolitan University have discovered a new mechanism by which clumps of tau protein are created in the brain, killing brain cells and causing Alzheimer’s disease. A specific mutation to an enzyme called MARK4 changed the properties of tau, usually an important part of the skeletal structure of cells,…

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